Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations.
Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system.Deuterium, 6NP in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo.Inferring these rates from labeling and delabeling curves has been